GlyCosmos Portal

Submissions

integrin subunit alpha 4

Summary

Gene Symbol

ITGA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3676

KEGG Gene ID

PubChem

3676

Alliance of Genome Resources

HGNC:6140

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Metal-binding
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P13612	CD49 antigen-like family member D Integrin alpha-IV VLA-4 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
immune response in gut-associated lymphoid tissue	NAS
positive regulation of leukocyte migration	IEA
cell-matrix adhesion involved in ameboidal cell migration	IMP
cell adhesion	IEA
leukocyte cell-cell adhesion	NAS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

leukocyte migration

diapedesis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-matrix adhesion involved in ameboidal cell migration

substrate adhesion-dependent cell spreading

cell adhesion mediated by integrin [inference]

cell-cell adhesion mediated by integrin

cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte adhesion to vascular endothelial cell [inference]

leukocyte tethering or rolling

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

endodermal cell differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration

diapedesis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

anatomical structure development [inference]

tissue development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

endodermal cell differentiation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

response to stimulus [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

response to nitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

import into cell

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of vascular endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying entries **11 - 15** of 19 in total

« First

‹ Prev

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
growth cone	IEA
integrin alpha4-beta1 complex	TAS
integrin alpha4-beta1 complex	IBA
integrin alpha4-beta1 complex	IPI
integrin alpha4-beta7 complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
fibronectin binding	IEA
antigen binding	IEA
integrin binding	TAS
protein binding	IPI
coreceptor activity	TAS

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein antigen binding

protein binding

fibronectin binding

signaling receptor binding [inference]

integrin binding

cytokine binding [inference]

chemokine binding [inference]

C-X3-C chemokine binding

cell adhesion molecule binding

integrin binding

protein antigen binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity

coreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16401	MGI:96603
Xenopus laevis	397839	Xenbase:XB-GENE-960094

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements