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Guidelines

MIRAGE

Peptidoglycan recognition protein LF

Summary

Gene Symbol

PGRP-LF

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39064

KEGG Gene ID

PubChem

39064

Alliance of Genome Resources

FB:FBgn0035977

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Innate immunity
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8SXQ7	PGRP-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
immune response	IBA
peptidoglycan catabolic process	IMR
peptidoglycan catabolic process	IKR
response to bacterium	IDA
antibacterial humoral response	IMP

GO Hierarchy

biological process

immune system process [inference]

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to other organism

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
plasma membrane	IDA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IPI
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IKR
N-acetylmuramoyl-L-alanine amidase activity	IMR
peptidoglycan binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidoglycan recognition protein

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
zinc ion binding

Displaying **all 4** entries
InterPro
N-acetylmuramoyl-L-alanine amidase domain
N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
Peptidoglycan recognition protein family domain, metazoa/bacteria
Peptidoglycan recognition protein

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
plasma membrane	PMID:12777387 PMID:17967349

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	242100	MGI:2685266
Mus musculus	384997	MGI:2686324
Homo sapiens	114771	HGNC:30014
Homo sapiens	57115	HGNC:30015

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026