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Guidelines

MIRAGE

peptidoglycan recognition protein 4

Summary

Gene Symbol

Pglyrp4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

384997

KEGG Gene ID

PubChem

384997

Alliance of Genome Resources

MGI:2686324

Annotation

Keyword

Antibiotic
Disulfide bond
Glycoprotein
Innate immunity
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q0VB07	Peptidoglycan recognition protein I-beta Peptidoglycan recognition protein intermediate beta
B7ZMZ4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

1

2

3

4

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Last »
GO Term	Evidence Code	PMID
immune response	IBA
peptidoglycan catabolic process	IEA
detection of bacterium	ISO
detection of bacterium	IEA
killing of cells of another organism	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

cellular process [inference]

cell killing [inference]

killing of cells of another organism

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

detection of other organism [inference]

detection of bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

detection of other organism [inference]

detection of bacterium

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

detection of other organism [inference]

detection of bacterium

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

detection of stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of natural killer cell differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of natural killer cell differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
protein-containing complex	ISO
protein-containing complex	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

extracellular region

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IBA
N-acetylmuramoyl-L-alanine amidase activity	IEA
peptidoglycan immune receptor activity	ISO
peptidoglycan immune receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity [inference]

peptidoglycan immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidoglycan recognition protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
N-acetylmuramoyl-L-alanine amidase activity
zinc ion binding

Displaying **all 4** entries
InterPro
N-acetylmuramoyl-L-alanine amidase domain
N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
Peptidoglycan recognition protein family domain, metazoa/bacteria
Peptidoglycan recognition protein

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	39064	FB:FBgn0035977
Drosophila melanogaster	39870	FB:FBgn0043578
Homo sapiens	57115	HGNC:30015

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026