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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

laminin subunit alpha 5

Summary

Gene Symbol

LAMA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

3911

KEGG Gene ID

PubChem

3911

Alliance of Genome Resources

HGNC:6485

Annotation

Keyword

3D-structure
Alternative splicing
Basement membrane
Cell adhesion
Coiled coil
Disease variant
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O15230	Laminin-10 subunit alpha Laminin-11 subunit alpha Laminin-15 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
branching involved in ureteric bud morphogenesis
morphogenesis of a polarized epithelium
hair follicle development
cell adhesion	IDA
cell adhesion	IEA

GO Hierarchy

biological process

cellular process [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell motility [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration [inference]

trunk neural crest cell migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

postsynapse organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

animal organ morphogenesis

odontogenesis [inference]

odontogenesis of dentin-containing tooth

skeletal system morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

anatomical structure development [inference]

hair follicle development

animal organ development [inference]

system development

muscle structure development [inference]

muscle organ development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

Displaying entries **16 - 20** of 26 in total

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GO Term	Evidence Code	PMID
laminin-511 trimer	TAS
laminin-511 trimer	IDA
laminin-511 trimer	IPI
laminin-511 trimer	IEA
laminin-521 trimer	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

laminin trimer [inference]

cellular anatomical structure [inference]

extracellular region

cell junction [inference]

synapse [inference]

external encapsulating structure [inference]

extracellular matrix

basement membrane

specialized extracellular matrix [inference]

extracellular matrix of synaptic cleft

synaptic cleft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IEA
integrin binding	IDA
integrin binding	IEA
extracellular matrix structural constituent	RCA
extracellular matrix structural constituent	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

laminin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
animal organ morphogenesis
tissue development

Displaying **all 5** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like domain
Laminin G domain
Laminin IV
Laminin-type EGF domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060993	bent bone dysplasia syndrome 2	Alliance of Genome Resources
DOID:2590	familial nephrotic syndrome	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16776	MGI:105382
Rattus norvegicus	140433	RGD:621023
Caenorhabditis elegans	177956	WB:WBGene00001328
Drosophila melanogaster	38723	FB:FBgn0002526

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026