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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

lysyl oxidase

Summary

Gene Symbol

LOX

Organism

Homo sapiens (human)

External Links

NCBI Gene

4015

KEGG Gene ID

PubChem

4015

Alliance of Genome Resources

HGNC:6664

Annotation

Keyword

Aortic aneurysm
Copper
Disease variant
Disulfide bond
Glycoprotein
LTQ
Metal-binding
Oxidoreductase
Proteomics identification
Reference proteome
Secreted
Signal
Sulfation
TPQ

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B0AZT2
B7ZAJ4
P28300	Lysyl oxidase
D0PNI2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation
heart development
response to xenobiotic stimulus	IEA
response to hormone	IEA
regulation of gene expression

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

macromolecule modification [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

elastic fiber assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development

cell development [inference]

muscle cell development

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to steroid hormone

response to chemical [inference]

response to xenobiotic stimulus

response to hormone

response to steroid hormone

response to lipid [inference]

response to steroid hormone

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

response to chemokine [inference]

cellular response to chemokine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of muscle organ development [inference]

regulation of striated muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
collagen trimer	IEA
obsolete extracellular space
extracellular matrix	IBA
extracellular matrix	IEA
elastic fiber	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

elastic fiber

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein-lysine 6-oxidase activity	ISS
protein-lysine 6-oxidase activity	EXP
protein-lysine 6-oxidase activity	TAS
protein-lysine 6-oxidase activity	IDA
protein-lysine 6-oxidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

diamine oxidase activity [inference]

protein-lysine 6-oxidase activity

catalytic activity, acting on a protein [inference]

protein-lysine 6-oxidase activity

binding [inference]

protein binding

small molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

protein-containing complex binding [inference]

collagen binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:1838	Menkes disease	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16948	MGI:96817

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026