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Guidelines

MIRAGE

podoplanin

Summary

Gene Symbol

PDPN

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene

403886

KEGG Gene ID

PubChem

403886

Annotation

Keyword

Cell junction
Cell membrane
Cell projection
Cell shape
Developmental protein
Direct protein sequencing
Reference proteome
Sialic acid
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q95152	Mucin-type membrane protein Gp40

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell morphogenesis	IEA
lymphangiogenesis	ISS
cell adhesion	IBA
cell adhesion	IEA
signal transduction	IBA

GO Hierarchy

biological process

cellular process [inference]

cell-cell adhesion

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

cell motility [inference]

wound healing, spreading of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

lymphangiogenesis

anatomical structure development [inference]

animal organ development [inference]

lung development

hematopoietic or lymphoid organ development [inference]

lymph node development

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

response to stimulus [inference]

response to stress [inference]

response to hyperoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to increased oxygen levels [inference]

response to hyperoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of myofibroblast contraction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of lamellipodium organization [inference]

regulation of lamellipodium morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
ruffle	ISS
cytosol	ISS
plasma membrane	ISS
membrane	ISS
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane microdomain [inference]

membrane raft

cell leading edge [inference]

leading edge of lamellipodium

leading edge membrane [inference]

cell projection

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

tetraspanin-enriched microdomain

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IEA
chemokine binding	IEA
protein-folding chaperone binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

cytokine binding [inference]

chemokine binding

protein-folding chaperone binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Podoplanin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
Rho protein signal transduction
actin-mediated cell contraction
chemokine binding
lung development
positive regulation of cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of extracellular matrix disassembly
positive regulation of platelet aggregation
protein-folding chaperone binding
regulation of lamellipodium morphogenesis

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Last updated: April 6, 2026