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Podoplanin

Summary

UniProt ID: Q95152
Gene Symbol: GP40 PDPN
Gene ID: 403886
Organism: Canis lupus familiaris (dog)

External Links

PubChem: Q95152
Re-Glyco: Q95152

Annotation

Keyword: Cell junction Cell membrane Cell projection Cell shape Developmental protein Direct protein sequencing Reference proteome Sialic acid Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
lymphangiogenesis	ISS	GO_REF
cell adhesion	IBA	GO_REF
cell adhesion	IEA	GO_REF
signal transduction	IBA	GO_REF
signal transduction	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

cell motility [inference]

cell migration

wound healing, spreading of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

lymphangiogenesis

anatomical structure formation involved in morphogenesis [inference]

lymphangiogenesis

anatomical structure development [inference]

animal organ development [inference]

lung development

hematopoietic or lymphoid organ development [inference]

lymph node development

cellular developmental process [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

lymphatic endothelial cell fate commitment

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of myofibroblast contraction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion [inference]

positive regulation of platelet aggregation

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of lamellipodium organization [inference]

regulation of lamellipodium morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of platelet activation [inference]

regulation of platelet aggregation [inference]

positive regulation of platelet aggregation

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	Reference
ruffle	ISS	GO_REF
cytosol	ISS	GO_REF
plasma membrane	ISS	GO_REF
membrane	ISS	GO_REF
membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane microdomain [inference]

membrane raft

cell leading edge [inference]

leading edge of lamellipodium

leading edge membrane [inference]

cell projection

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

tetraspanin-enriched microdomain

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWRVPVLLLVLGGAGLRVPAAGASTVRPDDIIPGVEDSVVTPGTEDSVVTPGAEDNVVTDGATEEPYESGLTPLVTKNTESVTDLHLEDGPTQESTVHAKEESQSTTTLNVVTSHSREKVGEDTETTVEKDGLATVTLVGIIVGVLLAIGFIGGIIIVVARKMSGRYSP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
25	O-linked (GalNAc...) threonine	UniProt
38	O-linked (GalNAc...) serine	UniProt
41	O-linked (GalNAc...) threonine	UniProt
44	O-linked (GalNAc...) threonine	UniProt
47	O-linked (GalNAc...) serine	UniProt
50	O-linked (GalNAc...) threonine	UniProt
59	O-linked (GalNAc...) threonine	UniProt
63	O-linked (GalNAc...) threonine	UniProt
72	O-linked (GalNAc...) threonine	UniProt
76	O-linked (GalNAc...) threonine	UniProt