GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

malate dehydrogenase 2

Summary

Gene Symbol

MDH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4191

HGNC

6971

KEGG Gene ID

hsa:4191

PubChem

4191

Alliance of Genome Resources

HGNC:6971

JoGo

MDH2

TogoVar

MDH2

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Epilepsy
Glycoprotein
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B3KTM1
G3XAL0
A0A024R4K3
P40926

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
gluconeogenesis	IEA
tricarboxylic acid cycle	TAS
tricarboxylic acid cycle	IMP
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

Displaying entries **6 - 10** of 12 in total

« First

‹ Prev

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
mitochondrion	HDA
mitochondrial matrix	ISS
mitochondrial matrix	TAS
mitochondrial matrix	IDA
mitochondrial matrix	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	IDA
RNA binding	HDA
catalytic activity	IEA
oxidoreductase activity	IEA
malate dehydrogenase activity	IEA

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

malate dehydrogenase

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-malate dehydrogenase activity
carboxylic acid metabolic process
catalytic activity
malate dehydrogenase activity
malate metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
tricarboxylic acid cycle

Displaying **all 7** entries
InterPro
L-lactate/malate dehydrogenase
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Lactate/malate dehydrogenase, C-terminal
Lactate/malate dehydrogenase, N-terminal
Malate dehydrogenase, active site
Malate dehydrogenase, type 1
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000146701

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00026

Name

malate dehydrogenase [EC:1.1.1.37]

References

Rhea

(S)-malate + NAD⁺

H⁺ + oxaloacetate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080433	developmental and epileptic encephalopathy 51	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 72 in total

1

2

3

4

5

…

Next ›

Last »
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000093	Proteinuria
HP:0000096	Glomerular sclerosis
HP:0000405	Conductive hearing impairment
HP:0000486	Strabismus
HP:0000510	Rod-cone dystrophy
HP:0000526	Aniridia
HP:0000740	Episodic paroxysmal anxiety
HP:0000790	Hematuria
HP:0000817	Reduced eye contact

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:29072	hereditary pheochromocytoma-paraganglioma
OMIM:617339	developmental and epileptic encephalopathy, 51

PubChem Disease

MedGen Diseases

Developmental and epileptic encephalopathy, 51

OMIM Phenotypes

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 51; DEE51

KEGG Diseases

Early infantile epileptic encephalopathy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	17448	MGI:97050
Rattus norvegicus	81829	RGD:619719
Saccharomyces cerevisiae S288C	853777	SGD:S000001568
Saccharomyces cerevisiae S288C	853994	SGD:S000005486

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: [email protected]

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026