GlyCosmos Portal

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GO Term	Evidence Code	PMID
protein kinase activity	IDA	15001576
protein serine/threonine kinase activity	EXP	7997270 9639556
protein serine/threonine kinase activity	IBA
JUN kinase kinase kinase activity	IEA
MAP kinase kinase kinase activity	NAS	9808624

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitogen-activated protein kinase kinase kinase 1

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
kinase activity
metal ion binding
nucleotide binding
phosphorylation
zinc ion binding

Displaying **all 8** entries
InterPro
Armadillo-like helical
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, SWIM-type

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080763	diffuse gastric cancer	Alliance of Genome Resources
DOID:0111769	46,XY sex reversal 6	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4214	Xenbase:XB-GENE-1008434
Mus musculus	26401		MOUSE11432
Rattus norvegicus	116667		RATNO24664
Sus scrofa	396617		PIGXX10631
Pan troglodytes	471543		PANTR35520
Canis lupus familiaris	478061		CANLF06708
Bos taurus	523962		BOVIN15915
Macaca mulatta	710979		MACMU38384
Rattus norvegicus	853350	RGD:620966
Monodelphis domestica	100032065		MONDO17175