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Negative elongation factor A

Summary

Gene Symbol

Nelf-A

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42520

KEGG Gene ID

PubChem

42520

Alliance of Genome Resources

FB:FBgn0038872

Annotation

Keyword

Chromosome
Developmental protein
Elongation factor
Nucleus
Reference proteome
Repressor
Transcription regulation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0B4LIF3
Q86NP2
A0A0B4KGH5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II	ISS
negative regulation of transcription elongation by RNA polymerase II	IDA
negative regulation of transcription elongation by RNA polymerase II	IBA

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IEA
chromosome	EXP
chromosome	IEA
transcription repressor complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

transcription regulator complex [inference]

transcription repressor complex

nuclear protein-containing complex [inference]

transcription elongation factor complex [inference]

NELF complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
RNA binding	ISS
translation elongation factor activity
molecular adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding

molecular adaptor activity

translation factor activity [inference]

translation elongation factor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
nucleus	PMID:20534440

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	24116	MGI:1346098
Homo sapiens	7469	HGNC:12768

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Last updated: April 6, 2026

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