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Guidelines

MIRAGE

Dicer-1

Summary

Gene Symbol

Dcr-1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42693

KEGG Gene ID

PubChem

42693

Annotation

Keyword

3D-structure
Cytoplasm
Endonuclease
Helicase
Magnesium
Manganese
Metal-binding
Phosphoprotein
RNA-binding
RNA-mediated gene silencing
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A515MFY5
Q9VCU9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
developmental process involved in reproduction	IEA
apoptotic DNA fragmentation	IBA
RNA processing	IEA
response to stress	IEA
pole cell formation	IMP

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

mitotic cell cycle, embryonic

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

cell population proliferation [inference]

germ-line cyst formation [inference]

female germ-line cyst formation [inference]

germarium-derived female germ-line cyst formation

cellular developmental process [inference]

cell fate determination [inference]

oocyte fate determination [inference]

germarium-derived oocyte fate determination

cell division [inference]

stem cell division [inference]

germ-line stem cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

developmental process [inference]

developmental process involved in reproduction

anatomical structure morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellularization [inference]

pole cell formation

anatomical structure development [inference]

system development

cellular developmental process [inference]

cell fate determination [inference]

oocyte fate determination [inference]

germarium-derived oocyte fate determination

response to stimulus [inference]

response to stress

response to starvation

response to nutrient levels [inference]

response to starvation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IBA
nucleus	IEA
cytoplasm	EXP
cytoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

ribonucleoprotein complex [inference]

RNAi effector complex [inference]

RISC complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
RNA binding	IBA
RNA binding	IEA
single-stranded RNA binding	IDA
helicase activity
RNA endonuclease activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism

ribonuclease III activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

binding [inference]

nucleic acid binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dicer

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair

Displaying **all 9** entries
Gene Ontology
ATP binding
RNA endonuclease activity, producing 5'-phosphomonoesters
deoxyribonuclease I activity
hydrolase activity
nuclease activity
nucleotide binding
pre-miRNA processing
regulatory ncRNA-mediated gene silencing
ribonuclease III activity

Displaying entries **1 - 10** of 13 in total

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InterPro
Dicer dimerisation domain superfamily
Dicer dimerisation domain
Dicer, double-stranded RNA-binding domain
Dicer, partner-binding domain
Dicer, platform domain
Double-stranded RNA-binding domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
PAZ domain superfamily

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026