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Endoribonuclease Dcr-1

Summary

UniProt ID: Q9VCU9
Gene Symbol: CG4792 Dcr-1
Gene ID: 42693
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: Q9VCU9
The O-GlcNAc Database: Q9VCU9
Re-Glyco: Q9VCU9

Annotation

Keyword: 3D-structure Cytoplasm Endonuclease Helicase Magnesium Manganese Metal-binding Phosphoprotein RNA-binding RNA-mediated gene silencing Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
apoptotic DNA fragmentation	IBA	GO_REF
pole cell formation	IMP	PMID
germarium-derived oocyte fate determination	IMP	PMID
segment polarity determination	IGI	PMID
siRNA processing	IDA	PMID PMID

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

mitotic cell cycle, embryonic

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process [inference]

apoptotic DNA fragmentation

RNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

cell population proliferation [inference]

germ-line cyst formation [inference]

female germ-line cyst formation [inference]

germarium-derived female germ-line cyst formation

cellular developmental process [inference]

cell fate determination [inference]

oocyte fate determination [inference]

germarium-derived oocyte fate determination

cell division [inference]

stem cell division [inference]

germ-line stem cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellularization [inference]

pole cell formation

cellular developmental process [inference]

cell fate determination [inference]

oocyte fate determination [inference]

germarium-derived oocyte fate determination

response to stimulus [inference]

response to stress [inference]

response to starvation

response to nutrient levels [inference]

response to starvation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
nucleus	IBA	GO_REF
nucleus	IEA	GO_REF
cytoplasm	EXP	PMID
cytoplasm	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

ribonucleoprotein complex [inference]

RNAi effector complex [inference]

RISC complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
RNA binding	IBA	GO_REF
RNA binding	IEA	GO_REF GO_REF
single-stranded RNA binding	IDA	PMID
helicase activity
RNA endonuclease activity	IDA	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 5'-phosphomonoesters [inference]

deoxyribonuclease I activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

binding [inference]

nucleic acid binding [inference]

RNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAFHWCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARRHGRVSVYLSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEGFLYLLETRELLLSSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHFYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPHLLTGASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRIAKCTAAKCALRQLKKQGLIAKKD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites