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Submissions

Toll

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43222

PubChem

43222

Alliance of Genome Resources

FB:FBgn0262473

Annotation

Keyword

3D-structure
Cell adhesion
Cell membrane
Cytoplasm
Developmental protein
Disulfide bond
Glycoprotein
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0B4KHY4
P08953

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
positive regulation of antimicrobial peptide production	IMP
defense response to oomycetes	IMP
response to tumor cell	IMP
positive regulation of antifungal peptide production	IDA
positive regulation of antifungal peptide production	IGI

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

antifungal innate immune response

cellular process [inference]

cell adhesion

signal transduction

cell surface receptor signaling pathway [inference]

cell competition in a multicellular organism

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

dorsal/ventral axis specification

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

muscle structure development [inference]

somatic muscle development [inference]

larval somatic muscle development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

antifungal innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to oomycetes

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

antifungal innate immune response

response to wounding

immune response [inference]

innate immune response

antifungal innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

antifungal innate immune response

response to biotic stimulus [inference]

response to tumor cell

response to external biotic stimulus [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

antifungal innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of hemocyte proliferation

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

cell competition in a multicellular organism

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of hemocyte proliferation

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell growth

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of developmental process [inference]

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell growth

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of embryonic pattern specification

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
early endosome	IDA
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

cleavage furrow

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

cell periphery

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IDA
cytokine receptor activity	IMP
protein binding	IPI
cytokine binding	IPI
signaling receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

TIR domain binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Toll

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
immune response
toll-like receptor signaling pathway

Displaying **all 7** entries
InterPro
Cysteine-rich flanking region, C-terminal
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat
Toll-like receptor
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
cleavage furrow	PMID:1879347
external side of plasma membrane	PMID:22464169
cell surface	PMID:1879347
membrane	FB:FBrf0231198
early endosome	PMID:20921412
plasma membrane	PMID:1879347 PMID:19154721 PMID:19317464 PMID:20404143 PMID:31088910 PMID:7635064

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:4194	glucose metabolism disease	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources
DOID:854	collagen disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements