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Protein toll
Summary
- UniProt ID
- P08953
- Gene Symbol
- CG5490 Tl
- Gene ID
- 43222
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
- 3D-structure Cell adhesion Cell membrane Cytoplasm Developmental protein Disulfide bond Glycoprotein Innate immunity Leucine-rich repeat NAD Receptor Reference proteome Repeat Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| positive regulation of antimicrobial peptide production | ||
| defense response to oomycetes | ||
| response to tumor cell | ||
| positive regulation of antifungal peptide production | ||
| positive regulation of antifungal peptide production |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| early endosome | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| transmembrane signaling receptor activity | ||
| cytokine receptor activity | ||
| cytokine binding | ||
| signaling receptor activity | ||
| identical protein binding |
GO Hierarchy
Sequence
MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 80 |
|
|
||
| 140 |
|
|
||
| 175 |
|
|
||
| 235 |
|
|
||
| 270 |
|
|
||
| 275 |
|
|
||
| 346 |
|
|
||
| 391 |
|
|
||
| 482 |
|
|
||
| 508 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' | Drosophila melanogaster |
| Adaptor protein complex binds to TL receptor at the plasma membrane | Drosophila melanogaster |
| DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' | Drosophila melanogaster |
| DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' | Drosophila melanogaster |
| Formation of the trans-membrane 'signalling complex' | Drosophila melanogaster |
| PLL kinase binds to TUB in the TL receptor 'signalling complex' | Drosophila melanogaster |
| Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' | Drosophila melanogaster |
