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Guidelines

MIRAGE

NPC1 like intracellular cholesterol transporter 1

Summary

Gene Symbol

Npc1l1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

432367

KEGG Gene ID

PubChem

432367

Alliance of Genome Resources

RGD:1303135

Annotation

Keyword

3D-structure
Cell membrane
Cholesterol metabolism
Disulfide bond
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IKS2
Q6T3U3	Niemann-Pick C1-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
cholesterol biosynthetic process	ISO
cholesterol metabolic process
response to xenobiotic stimulus	IEP
response to muscle activity	IEP
sterol transport	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

vitamin E metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

protein metabolic process [inference]

lipoprotein metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion

cellular response to stress [inference]

cellular response to sterol depletion

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport

cholesterol import

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

cholesterol import

vitamin transport

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	EXP
plasma membrane	IBA
plasma membrane	IEA
endomembrane system

GO Hierarchy

cellular component

cellular anatomical structure [inference]

endomembrane system

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
lipid carrier activity	IEA
vitamin E binding	ISO
cholesterol binding	ISO
cholesterol binding	IBA
small GTPase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

myosin binding [inference]

myosin V binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

vitamin binding [inference]

vitamin E binding

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding

vitamin E binding

molecular carrier activity [inference]

lipid carrier activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cholesterol binding
intestinal cholesterol absorption
lipid transport
sterol transport

Displaying **all 3** entries
InterPro
Niemann-Pick C1, N-terminal
Protein patched/dispatched
Sterol-sensing domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:15777641

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	180719	WB:WBGene00003561
Drosophila melanogaster	33072	FB:FBgn0261675
Homo sapiens	29881	HGNC:7898
Saccharomyces cerevisiae S288C	856101	SGD:S000005927

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026