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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

myeloperoxidase

Summary

Gene Symbol

MPO

Organism

Homo sapiens (human)

External Links

NCBI Gene

4353

KEGG Gene ID

PubChem

4353

Alliance of Genome Resources

HGNC:7218

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Lysosome
Oxidation
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P05164

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
response to yeast
hypochlorous acid biosynthetic process
respiratory burst involved in defense response
nucleosome disassembly	IDA
defense response	TAS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell

respiratory burst involved in defense response

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell

killing of cells of another organism [inference]

neutrophil-mediated killing of symbiont cell

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

hypochlorous acid biosynthetic process

reactive oxygen species biosynthetic process [inference]

hypochlorous acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

hypochlorous acid biosynthetic process

small molecule biosynthetic process [inference]

hypochlorous acid biosynthetic process

respiratory burst [inference]

respiratory burst involved in defense response

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species biosynthetic process [inference]

hypochlorous acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome disassembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein-DNA complex disassembly [inference]

nucleosome disassembly

cellular component assembly [inference]

neutrophil extracellular trap formation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein-DNA complex disassembly [inference]

nucleosome disassembly

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

protein-DNA complex organization [inference]

protein-DNA complex disassembly [inference]

nucleosome disassembly

nucleosome organization [inference]

nucleosome disassembly

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

cellular detoxification [inference]

cellular oxidant detoxification

removal of superoxide radicals

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

neutrophil-mediated killing of symbiont cell

response to stimulus [inference]

response to stress [inference]

defense response

response to oxidative stress

response to external stimulus [inference]

response to mechanical stimulus

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

response to abiotic stimulus [inference]

response to mechanical stimulus

response to nutrient levels [inference]

response to food

response to chemical [inference]

response to food

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to transition metal nanoparticle [inference]

response to gold nanoparticle

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

removal of superoxide radicals

Displaying entries **16 - 20** of 20 in total

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GO Term	Evidence Code	PMID
azurophil granule	IDA
phagocytic vesicle	IDA
extracellular exosome	HDA
phagocytic vesicle lumen	TAS
neutrophil extracellular trap	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

endocytic vesicle lumen [inference]

phagocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

extracellular membraneless organelle [inference]

neutrophil extracellular trap

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

primary lysosome [inference]

azurophil granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

azurophil granule

extracellular organelle [inference]

extracellular membraneless organelle [inference]

neutrophil extracellular trap

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromatin binding	TAS
peroxidase activity	TAS
peroxidase activity	IDA
peroxidase activity	IBA
peroxidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

chromatin binding

nucleosome binding

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

nucleosome binding

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

antioxidant activity [inference]

peroxidase activity

protein-containing complex destabilizing activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:850	lung disease	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3021	acute kidney failure	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:865	vasculitis	Alliance of Genome Resources
DOID:0080348	Alzheimer's disease 1	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	17523	MGI:97137
Caenorhabditis elegans	191484	WB:WBGene00004256
Caenorhabditis elegans	181288	WB:WBGene00004257
Drosophila melanogaster	38326	FB:FBgn0011828

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026