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MRE11 double strand break repair nuclease

Summary

Gene Symbol

MRE11

Organism

Homo sapiens (human)

External Links

NCBI Gene

4361

KEGG Gene ID

[""]

PubChem

4361

Alliance of Genome Resources

HGNC:7230

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Ciliopathy
DNA repair
Disease variant
Endonuclease
Exonuclease
Host-virus interaction
Isopeptide bond
Manganese
Meiosis
Methylation
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Telomere
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F8W7U8
P49959	Meiotic recombination 11 homolog 1 Meiotic recombination 11 homolog A
Q05D78	Meiotic recombination 11 homolog A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
regulation of mitotic recombination	TAS
telomere maintenance	IBA
double-strand break repair via homologous recombination	IDA
double-strand break repair via homologous recombination	IBA
double-strand break repair via homologous recombination	IEA

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA double-strand break processing

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

homologous recombination

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

meiotic DNA double-strand break formation

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

DNA strand resection involved in replication fork processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA double-strand break processing

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

homologous recombination

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

meiotic DNA double-strand break formation

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

DNA strand resection involved in replication fork processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cell population proliferation

cell cycle process [inference]

sister chromatid cohesion

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA double-strand break formation

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

organelle organization [inference]

chromosome organization

sister chromatid cohesion

telomere organization [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

reproductive process [inference]

meiotic cell cycle

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA double-strand break formation

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

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GO Term	Evidence Code	PMID
single-stranded DNA endonuclease activity	TAS
single-stranded DNA endonuclease activity	IDA
single-stranded DNA endonuclease activity	IBA
DNA binding	IDA
DNA helicase activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

single-stranded DNA endonuclease activity

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

3'-5' exonuclease activity

3'-5'-DNA exonuclease activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity [inference]

DNA helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

3'-5' exonuclease activity

3'-5'-DNA exonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding

protein binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

double-strand break repair protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
3'-5'-DNA exonuclease activity
DNA endonuclease activity
DNA repair
double-strand break repair via nonhomologous end joining
double-strand break repair
endonuclease activity
hydrolase activity
manganese ion binding
meiotic DNA double-strand break formation
mitochondrial double-strand break repair via homologous recombination

Displaying **all 6** entries
InterPro
Calcineurin-like phosphoesterase domain, ApaH type
DNA double-strand break repair protein Mre11
Metallo-dependent phosphatase-like
Mre11 nuclease, N-terminal metallophosphatase domain
Mre11, DNA-binding
Mre11, capping domain

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0081384	ataxia-telangiectasia-like disorder 1	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements