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Double-strand break repair protein MRE11

Summary

UniProt ID: P49959
Gene Symbol: MRE11 HNGS1 MRE11A
Gene ID: 4361
Organism: Homo sapiens (human)

External Links

GlyGen: P49959
PubChem: P49959
The Human Metabolome Database: HMDBP08845
The O-GlcNAc Database: P49959
O-GlcNAcAtlas: P49959
Re-Glyco: P49959

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Ciliopathy DNA repair Disease variant Endonuclease Exonuclease Host-virus interaction Isopeptide bond Manganese Meiosis Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Telomere Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	Reference
regulation of mitotic recombination	TAS	PMID
telomere maintenance	IBA	GO_REF
double-strand break repair via homologous recombination	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
double-strand break repair via homologous recombination	IBA	GO_REF
double-strand break repair via homologous recombination	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA double-strand break processing

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

homologous recombination

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

meiotic DNA double-strand break formation

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

DNA strand resection involved in replication fork processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA double-strand break processing

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

homologous recombination

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

meiotic DNA double-strand break formation

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

DNA strand resection involved in replication fork processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cell population proliferation

cell cycle process [inference]

sister chromatid cohesion

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA double-strand break formation

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion

telomere organization [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

reproductive process [inference]

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA double-strand break formation

chromosome organization involved in meiotic cell cycle [inference]

homologous chromosome pairing at meiosis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair

mitochondrial double-strand break repair [inference]

mitochondrial double-strand break repair via homologous recombination

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of mitotic recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via nonhomologous end joining

positive regulation of double-strand break repair

regulation of double-strand break repair via nonhomologous end joining [inference]

negative regulation of double-strand break repair via nonhomologous end joining

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
single-stranded DNA endonuclease activity	TAS	PMID
single-stranded DNA endonuclease activity	IDA	PMID
single-stranded DNA endonuclease activity	IBA	GO_REF
double-stranded DNA binding	TAS	PMID
nuclease activity	TAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

single-stranded DNA endonuclease activity

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

3'-5' exonuclease activity

3'-5'-DNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity

endonuclease activity [inference]

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

3'-5' exonuclease activity

3'-5'-DNA exonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

single-stranded DNA endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding

protein binding [inference]

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	PubMed ID	GlyTouCan ID	Source
605	23301498 28411811 32119511 33465208 34019948 35164752 35254053 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
667	23301498 28411811 32119511 33465208 34019948 35164752 35254053 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
668	23301498 28411811 32119511 33465208 34019948 35164752 35254053 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 22 in total

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Pathway Name	Organism
Cytosolic sensors of pathogen-associated DNA	Homo sapiens
DNA Damage/Telomere Stress Induced Senescence	Homo sapiens
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	Homo sapiens
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Homo sapiens
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	Homo sapiens
G2/M DNA damage checkpoint	Homo sapiens
HDR through Homologous Recombination (HRR)	Homo sapiens
HDR through MMEJ (alt-NHEJ)	Homo sapiens
HDR through Single Strand Annealing (SSA)	Homo sapiens
Homologous DNA Pairing and Strand Exchange	Homo sapiens

Human Protein Atlas

ENSG00000020922

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources
DOID:0081384	ataxia-telangiectasia-like disorder 1	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements