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HDR through Homologous Recombination (HRR)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5685942

PubChem

R-HSA-5685942

Description

Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double-strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled fashion, creating invasive RAD51 nucleofilaments. The RAD51 nucleofilament invades a sister chromatid DNA duplex, leading to D-loop formation. After the D-loop is extended by DNA repair synthesis, the resulting recombination intermediates in the form of extended D-loops or double Holliday junctions can be resolved through crossover- or non-crossover-generating processes (reviewed by Ciccia and Elledge 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 31 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15315	DNA repair protein RAD51 homolog 2	RAD51B RAD51L1 REC2	view
O43502	DNA repair protein RAD51 homolog 3	RAD51C RAD51L2	view
O60934	Nibrin	NBN NBS NBS1 P95	view
P12004	DNA sliding clamp PCNA	PCNA	view
P15927	Replication protein A 32 kDa subunit	REPA2 RPA2 RPA32 RPA34	view
P27694	Replication protein A 70 kDa DNA-binding subunit	REPA1 RPA1 RPA70	view
P28340	DNA polymerase delta catalytic subunit	POLD POLD1	view
P35249	Replication factor C subunit 4	RFC4	view
P35251	Replication factor C subunit 1	RFC1 RFC140	view
P38398	Breast cancer type 1 susceptibility protein	BRCA1 RNF53	view

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