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DNA repair protein RAD51 homolog 3

Summary

UniProt ID: O43502
Gene Symbol: RAD51C RAD51L2
Gene ID: 5889
Organism: Homo sapiens (human)

External Links

PubChem: O43502
The O-GlcNAc Database: O43502
Re-Glyco: O43502

Annotation

Keyword: 3D-structure ATP-binding Alternative splicing Cytoplasm DNA recombination DNA repair DNA-binding Disease variant Fanconi anemia Mitochondrion Nucleus Phosphoprotein Proteomics identification Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
meiotic DNA recombinase assembly	IBA	GO_REF
telomere maintenance via recombination	IEA	GO_REF
double-strand break repair via homologous recombination	NAS	PMID
double-strand break repair via homologous recombination	IMP	PMID
DNA repair	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cell cycle process [inference]

sister chromatid cohesion

meiotic sister chromatid cohesion [inference]

female meiosis sister chromatid cohesion

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA recombinase assembly

meiosis I [inference]

male meiosis I

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

chromosome organization [inference]

sister chromatid cohesion

meiotic sister chromatid cohesion [inference]

female meiosis sister chromatid cohesion

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

DNA repair complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

DNA repair complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

protein-DNA complex organization [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA recombinase assembly

meiosis I [inference]

male meiosis I

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
nucleus	TAS	PMID
nucleus	IDA	PMID PMID
nucleus	IEA	GO_REF GO_REF
nucleoplasm	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
nucleoplasm	IDA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

DNA recombinase mediator complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
DNA binding	TAS	PMID
DNA binding	IEA	GO_REF
ATP binding	IEA	GO_REF
crossover junction DNA endonuclease activity	IMP	PMID
crossover junction DNA endonuclease activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

nucleic acid binding [inference]

DNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

molecular sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSLSTRKRSRDPEEEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
60		29237092	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	Homo sapiens
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Homo sapiens
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	Homo sapiens
Factors involved in megakaryocyte development and platelet production	Homo sapiens
HDR through Homologous Recombination (HRR)	Homo sapiens
Homologous DNA Pairing and Strand Exchange	Homo sapiens
Impaired BRCA2 binding to PALB2	Homo sapiens
Meiotic recombination	Homo sapiens
Presynaptic phase of homologous DNA pairing and strand exchange	Homo sapiens
Resolution of D-loop Structures through Holliday Junction Intermediates	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:5683	hereditary breast ovarian cancer syndrome	Alliance of Genome Resources
DOID:0111096	Fanconi anemia complementation group O	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements