Factors involved in megakaryocyte development and platelet production

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
RAD51BRAD51B:RAD51CRAD51CRAD51B:RAD51C:Single-stranded DNASingle-stranded DNADual-specific AKAPsDual-specific AKAPs:PKA tetramerPKA tetramerMitofusinsMitofusin complexSIN3Ap53:MYB:SIN3ATP53 TetramerMYBIFNA genesIRF1:Promotors of IFN alpha, IFN betaIRF1IFNB1 geneType-I IFN genesIFNA/BIRF2:promoters of INF alpha, INF betaIRF2CBX5HP1alpha:Histone H3 methylated at K9Histone H3 methylated at lysine-9I(3,4,5,6)P4I(1,3,4,5,6)P5ATPADPI(1,3,4,5)P4I(1,3,4)P3I(1,3,4,6)P4LRRC16ALRRC16A:F-actin capping proteinCPCAPZACAPZBF-actin capping protein:f-actinf-actinTPNHH2O2TPNO2REST:REST DNA binding sitesBHC complex:REST:REST DNA binding sitesBHC complexZFPM1, ZFPM2ZFPM proteins:GATA proteinsGATA proteinsHistone H3 mono or di-methylated at K9Histone H3 mono- or unmethylated at K9p-Y813-JAK2SH2B family:p-Y813-JAK2SH2B familyAMPGDPGTPADPNFE2NF-E2Small Maf family membersNF-E2:Promoter region of beta-globinPromotor region of beta-globinGlobin genesHBBHBDHBE1HBG1HBG2C-terminal EH domain containing proteinsC-terminal EH domain containing proteins:Rabenosyn-5ZFYVE20Rabenosyn-5:VPS-45RAB5AVPS45RAC1, CDC42DOCK-GEFs:RAC1, CDC42DOCK-GEFsCABLESCDK5:CABLES:ABLCDK5ABL1CABLES1CDK2:CABLES1:WEE1CDK2WEE1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 51 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O15315 DNA repair protein RAD51 homolog 2
  • RAD51B
  • RAD51L1
  • REC2
view
O15525 Transcription factor MafG
  • MAFG
view
O43502 DNA repair protein RAD51 homolog 3
  • RAD51C
  • RAD51L2
view
O60341 Lysine-specific histone demethylase 1A
  • AOF2
  • KDM1
  • KDM1A
  • KIAA0601
  • LSD1
view
O60675 Transcription factor MafK
  • MAFK
view
P00519 Tyrosine-protein kinase ABL1
  • ABL
  • ABL1
  • JTK7
view
P01563 Interferon alpha-2
  • IFNA2
  • IFNA2A
  • IFNA2B
  • IFNA2C
view
P01570 Interferon alpha-14
  • IFNA14
view
P01574 Interferon beta
  • IFB
  • IFNB
  • IFNB1
view
P04637 Cellular tumor antigen p53
  • P53
  • TP53
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025