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metabotropic Glutamate Receptor

Summary

Gene Symbol

mGluR

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43838

PubChem

43838

Alliance of Genome Resources

FB:FBgn0019985

Annotation

Keyword

Cell membrane
G-protein coupled receptor
Glycoprotein
Receptor
Reference proteome
Signal
Transducer
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
C5WLT4
X2JBI2
P91685
L0MPZ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IEA
G protein-coupled glutamate receptor signaling pathway	ISS	10908591
G protein-coupled glutamate receptor signaling pathway	IDA	10821630
G protein-coupled glutamate receptor signaling pathway	IBA
neuromuscular junction development	IMP	15483129

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

presynapse organization [inference]

terminal button organization

reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male courtship behavior

male mating behavior [inference]

male courtship behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

memory [inference]

behavior [inference]

learning or memory [inference]

learning

memory [inference]

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male courtship behavior

male mating behavior [inference]

male courtship behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	10821630 12923296
plasma membrane	IBA
membrane	ISS	10908591
membrane	IEA
G protein-coupled receptor homodimeric complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

G protein-coupled receptor homodimeric complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

G protein-coupled receptor homodimeric complex

cellular anatomical entity [inference]

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
group II metabotropic glutamate receptor activity	IDA	10821630
group II metabotropic glutamate receptor activity	IBA
G protein-coupled receptor activity	ISS	12163486
G protein-coupled receptor activity	IEA
glutamate receptor activity	ISS	10908591

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

amide binding [inference]

glutamate binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

alcohol binding [inference]

cholesterol binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 6** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
plasma membrane	PMID:10821630 PMID:12923296
membrane	FB:FBrf0231198
membrane raft	PMID:12923296

Ortholog

Displaying entries **11 - 17** of 17 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	24419	WB:WBGene00003232
Xenopus tropicalis	43838	Xenbase:XB-GENE-977445
Caenorhabditis elegans	60590	WB:WBGene00003232
Xenopus tropicalis	108068	Xenbase:XB-GENE-1012087
Xenopus tropicalis	108069	Xenbase:XB-GENE-977445
Xenopus tropicalis	191707	Xenbase:XB-GENE-977445
Caenorhabditis elegans	268934	WB:WBGene00003232

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements