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nibrin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4683

KEGG Gene ID

[""]

PubChem

4683

Alliance of Genome Resources

HGNC:7652

Annotation

Keyword

3D-structure
Cell cycle
DNA repair
Direct protein sequencing
Disease variant
Host-virus interaction
Isopeptide bond
Meiosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Telomere
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O60934	Cell cycle regulatory protein p95 Nijmegen breakage syndrome protein 1
A0A0C4DG07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 45 in total

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GO Term	Evidence Code	PMID
DNA damage checkpoint signaling	IDA
telomere maintenance	IMP
telomere maintenance	IEA
double-strand break repair via homologous recombination	IDA
double-strand break repair via homologous recombination	IBA

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cell cycle [inference]

meiotic cell cycle

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

DNA double-strand break processing

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

homologous recombination

DNA strand elongation [inference]

telomeric 3' overhang formation

DNA strand resection involved in replication fork processing

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K63-linked ubiquitination

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

telomere maintenance via telomere trimming

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

reproductive process [inference]

meiotic cell cycle

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

growth [inference]

developmental growth [inference]

blastocyst growth

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

double-strand break repair via nonhomologous end joining [inference]

double-strand break repair via alternative nonhomologous end joining

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

telomere maintenance in response to DNA damage

protection from non-homologous end joining at telomere

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to site of double-strand break

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of telomere maintenance

regulation of telomere capping [inference]

negative regulation of telomere capping

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance

regulation of cell cycle

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic G2 DNA damage checkpoint signaling

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint

mitotic G2 DNA damage checkpoint signaling

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

positive regulation of double-strand break repair via homologous recombination

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IC
damaged DNA binding	IBA
damaged DNA binding	IEA
protein binding	IPI
histone binding	IPI

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding

histone binding

modification-dependent protein binding [inference]

phosphorylation-dependent protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nibrin

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
DNA duplex unwinding
cell cycle
damaged DNA binding
double-strand break repair

Displaying **all 8** entries
InterPro
BRCT domain superfamily
BRCT domain
Forkhead-associated (FHA) domain
Nibrin, C-terminal
Nibrin, second BRCT domain superfamily
Nibrin, second BRCT domain
Nibrin-related
SMAD/FHA domain superfamily

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:12449	aplastic anemia	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1993	rectum cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:7400	Nijmegen breakage syndrome	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements