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nidogen 1

Summary

Gene Symbol

NID1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4811

PubChem

4811

Alliance of Genome Resources

HGNC:7821

Annotation

Keyword

Alternative splicing
Basement membrane
Calcium
Cell adhesion
Disulfide bond
EGF-like domain
Glycoprotein
Reference proteome
Repeat
Signal
Sulfation

Proteins

Displaying 1 entry
UniProt	Protein Name
P14543	Entactin

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IEA
positive regulation of cell-substrate adhesion	IEA
glomerular basement membrane development	IEA
positive regulation of cell adhesion	NAS	3794389
positive regulation of muscle cell differentiation	NAS	26555376

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

developmental process [inference]

anatomical structure development [inference]

glomerular basement membrane development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	NAS	1678389
basement membrane	IDA	22952693
plasma membrane
collagen-containing extracellular matrix	ISS	22261194

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	RCA	20551380 25037231 27068509 27559042 28675934
extracellular matrix structural constituent	ISS
calcium ion binding	IEA
collagen binding	IDA	22952693
Wnt-protein binding

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

Wnt-protein binding

laminin binding

laminin-1 binding

proteoglycan binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding [inference]

laminin binding

laminin-1 binding

carbohydrate derivative binding [inference]

proteoglycan binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

Wnt receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

low-density lipoprotein receptor-related protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Low-density lipoprotein (LDL) receptor class A repeat

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4811	Xenbase:XB-GENE-484718
Mus musculus	18073	Xenbase:XB-GENE-1003556	MOUSE11921
Drosophila melanogaster	18074	FB:FBgn0026403
Drosophila melanogaster	22795	FB:FBgn0026403
Rattus norvegicus	25494		RATNO13012
Xenopus tropicalis	36089	Xenbase:XB-GENE-1003556
Xenopus tropicalis	179770	Xenbase:XB-GENE-484718
Drosophila melanogaster	302248	FB:FBgn0026403
Pan troglodytes	469718		PANTR23981
Canis lupus familiaris	488958		CANLF14532