GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Disease variant
Epilepsy
Golgi apparatus
Mitochondrion
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P49419	Aldehyde dehydrogenase family 7 member A1 Antiquitin-1 Betaine aldehyde dehydrogenase Delta1-piperideine-6-carboxylate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
aldehyde metabolic process	ISS
obsolete lysine catabolic process
Golgi to endosome transport	IDA
sensory perception of sound	TAS
endosome to lysosome transport	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process

modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

catabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

amine catabolic process [inference]

biogenic amine catabolic process [inference]

choline catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

amine metabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

choline catabolic process

choline metabolic process [inference]

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

intercellular transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

plasma membrane to endosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

plasma membrane to endosome transport

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
Golgi membrane	EXP
Golgi membrane	IDA
Golgi membrane	IEA
nucleus	EXP
nucleus	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase (NAD+) activity	ISS
aldehyde dehydrogenase (NAD+) activity	EXP
aldehyde dehydrogenase (NAD+) activity	IDA
aldehyde dehydrogenase (NAD+) activity	IMP
aldehyde dehydrogenase (NAD+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

betaine-aldehyde dehydrogenase (NAD+) activity

L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 5** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Human Protein Atlas

ENSG00000164904

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K14085

Name

aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]

References

20207735

Rhea

RHEA:25294

acetaldehyde + H₂O + NAD⁺

H⁺ + acetate + NADH

Enzyme

1.2.1.3

PMID

RHEA:12304

H₂O + (S)-2-amino-6-oxohexanoate + NADP⁺

H⁺ + NADPH + L-2-aminoadipate

Enzyme

1.2.1.31

PMID

RHEA:15305

H₂O + betaine aldehyde + NAD⁺

H⁺ + glycine betaine + NADH

Enzyme

1.2.1.8

PMID

RHEA:16185

H₂O + an aldehyde + NAD⁺

H⁺ + a carboxylate + NADH

Enzyme

PMID

RHEA:12308

H₂O + NAD⁺ + (S)-2-amino-6-oxohexanoate

H⁺ + NADH + L-2-aminoadipate

Enzyme

1.2.1.31

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070519	early-onset vitamin B6-dependent epilepsy 4	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 41 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000238	Hydrocephalus
HP:0000273	Facial grimacing
HP:0000486	Strabismus
HP:0000496	Abnormality of eye movement
HP:0000711	Restlessness
HP:0000737	Irritability
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001250	Seizure