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Guidelines

MIRAGE

pyruvate dehydrogenase kinase 2

Summary

Gene Symbol

PDK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5164

KEGG Gene ID

PubChem

5164

Alliance of Genome Resources

HGNC:8810

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Kinase
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15119	Pyruvate dehydrogenase kinase isoform 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
glucose metabolic process	TAS
regulation of gluconeogenesis	ISS
regulation of gluconeogenesis	IEA
regulation of pH	ISS
regulation of pH	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to nutrient levels [inference]

cellular response to nutrient

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of pH

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of phosphorus metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

regulation of nucleobase-containing compound metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of pyruvate decarboxylation to acetyl-CoA

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleoplasm
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HTP

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

alpha-ketoacid dehydrogenase complex [inference]

pyruvate dehydrogenase complex

transferase complex [inference]

acetyltransferase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein kinase activity	TAS
protein kinase activity	IEA
pyruvate dehydrogenase (acetyl-transferring) kinase activity	TAS
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IDA
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

pyruvate dehydrogenase (acetyl-transferring) kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

pyruvate dehydrogenase (acetyl-transferring) kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

pyruvate dehydrogenase (acetyl-transferring) kinase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18604	MGI:1343087
Rattus norvegicus	81530	RGD:69428

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026