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phospholipase C epsilon 1

Summary

Gene Symbol

PLCE1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 519037
KEGG Gene ID: bta:519037
PubChem: 519037

Annotation

Keyword

Lipid degradation
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
F1MTE8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lipid metabolic process	IEA	22301074
small GTPase mediated signal transduction	IEA	22301074
phosphatidylinositol-mediated signaling	IEA	30032202
release of sequestered calcium ion into cytosol	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	IEA	22301074 30032202
guanyl-nucleotide exchange factor activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol
small GTPase-mediated signal transduction

Displaying entries **1 - 10** of 16 in total

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InterPro
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, EF-hand domain
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, RA domain 2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, catalytic domain
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain

KEGG BRITE Database

Orthology

K05860

Name

phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]

References

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	51196	HUMAN02224
Mus musculus	74055	MOUSE25598
Rattus norvegicus	114633	RATNO18849
Pan troglodytes	450620	PANTR01195
Canis lupus familiaris	486808	CANLF11321
Danio rerio	568288	DANRE03908
Macaca mulatta	701758	MACMU45738
Monodelphis domestica	100023487	MONDO07784
Equus caballus	100061676	HORSE17765
Sus scrofa	100157745	PIGXX08175