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MIRAGE

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Summary

Gene Symbol

PLOD2

Aliases

LH2
TLH
lysyl hydroxlase 2
procollagen lysyl hydroxylase 2
telopeptidyl lysyl hydroxylase

Organism

Homo sapiens (human)

External Links

NCBI Gene

5352

HGNC

9082

PubChem

5352

Alliance of Genome Resources

HGNC:9082

Annotation

Keyword

Alternative splicing
Dioxygenase
Disease variant
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Osteogenesis imperfecta
Phosphoprotein
Reference proteome
Signal
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
O00469	Lysyl hydroxylase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein modification process	TAS	9054364
hydroxylysine biosynthetic process	IDA	10934207

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
Golgi apparatus	IBA
rough endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

bounding membrane of organelle [inference]

rough endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
procollagen glucosyltransferase activity	IDA	10934207

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

procollagen glucosyltransferase activity

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Procollagen-lysine,2-oxoglutarate 5-dioxygenase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 4** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060231	Bruck syndrome	Glyco-Disease Genes Database

Ortholog

Displaying entries **31 - 40** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sarcophilus harrisii	100928031		SARHA18201
Otolemur garnettii	100954388		OTOGA12407
Pan paniscus	100969240		PANPA28998
Papio anubis	101010314		PAPAN24909
Saimiri boliviensis boliviensis	101039285		SAIBB18329
Felis catus	101085741		FELCA22263
Ovis aries	101103613		SHEEP01758
Gorilla gorilla gorilla	101123821		GORGO29254
Oryzias latipes	101171207		ORYLA09173
Jaculus jaculus	101601845		JACJA15241

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Last updated: April 7, 2025