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neuronal guanine nucleotide exchange factor

Summary

Gene Symbol

Ngef

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

53972

KEGG Gene ID

PubChem

53972

Alliance of Genome Resources

MGI:1858414

Annotation

Keyword

Alternative splicing
Cell projection
Cytoplasm
Developmental protein
Differentiation
Guanine-nucleotide releasing factor
Membrane
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8CHT1	Eph-interacting exchange protein Neuronal guanine nucleotide exchange factor
E9QK62	Eph-interacting exchange protein Neuronal guanine nucleotide exchange factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nervous system development
cell differentiation
regulation of actin cytoskeleton organization	IBA
regulation of GTPase activity	IDA
ephrin receptor signaling pathway	IDA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of dendritic spine development [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

regulation of synapse pruning

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of GTPase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
cytosol	TAS
membrane	IEA
growth cone	IEA
postsynapse	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone

postsynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA
guanyl-nucleotide exchange factor activity	IEA
protein binding	IPI
ephrin receptor binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

ephrin receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
Ephexin-like, PH domain
Ephexin-like
PH-like domain superfamily
Pleckstrin homology domain
SH3 domain
SH3-like domain superfamily