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Ephexin-1

Summary

UniProt ID: Q8CHT1
Gene Symbol: Ngef
Gene ID: 53972
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8CHT1
PubChem: Q8CHT1
Re-Glyco: Q8CHT1

Annotation

Keyword: Alternative splicing Cell projection Cytoplasm Developmental protein Differentiation Guanine-nucleotide releasing factor Membrane Neurogenesis Phosphoprotein Reference proteome SH3 domain

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
nervous system development
cell differentiation
regulation of actin cytoskeleton organization	IBA	GO_REF
regulation of GTPase activity	IDA	PMID
ephrin receptor signaling pathway	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of dendritic spine development [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis [inference]

negative regulation of dendritic spine morphogenesis

regulation of synapse pruning

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of GTPase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
cytosol	TAS	Reactome
membrane	IEA	GO_REF
growth cone	IEA	GO_REF
postsynapse	ISO	GO_REF
glutamatergic synapse	IEP	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	Reference
guanyl-nucleotide exchange factor activity	ISO	GO_REF
guanyl-nucleotide exchange factor activity	IBA	GO_REF
guanyl-nucleotide exchange factor activity	IEA	GO_REF
ephrin receptor binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

ephrin receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

METKNSEDWGKPQRKSESSSRKSNHGPAEMRPALPPENREAPETGEETQNEEPRRLIPIQRHSLFNRAVRHRHKARSTSERRASDQADLPKMGKSVNERSAFNLPQGRLSPWRTPAQRDTGAQEASESSSTPGNGTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQVGEDAGEEEEEEEEGEEEELASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
131				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
CDC42 GTPase cycle	Mus musculus
EPHA-mediated growth cone collapse	Mus musculus
G alpha (12/13) signalling events	Mus musculus
NRAGE signals death through JNK	Mus musculus
RAC1 GTPase cycle	Mus musculus
RHOA GTPase cycle	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements