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transient receptor potential cation channel subfamily M member 4

Summary

Gene Symbol

TRPM4

Organism

Homo sapiens (human)

External Links

NCBI Gene

54795

PubChem

54795

Alliance of Genome Resources

HGNC:17993

Annotation

Keyword

3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Calcium
Calmodulin-binding
Cell membrane
Coiled coil
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Ion channel
Metal-binding
Palmoplantar keratoderma
Phosphoprotein
Receptor
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DIX5
Q8TD43	Calcium-activated non-selective cation channel 1 Long transient receptor potential channel 4 Melastatin-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
dendritic cell chemotaxis	ISS
regulation of T cell cytokine production	IDA	20656926
positive regulation of cytosolic calcium ion concentration	ISS
positive regulation of cell population proliferation	IDA	20625999

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

response to stimulus [inference]

immune response [inference]

adaptive immune response

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organic cyclic compound [inference]

cellular response to ATP

response to organophosphorus [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to oxygen-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

response to salt [inference]

response to ATP [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

calcium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of leukocyte mediated immunity [inference]

regulation of lymphocyte mediated immunity [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of immune response [inference]

regulation of adaptive immune response [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of adipose tissue development

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of adipose tissue development

positive regulation of membrane depolarization [inference]

positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of immune response [inference]

regulation of adaptive immune response [inference]

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell cytokine production

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of adipose tissue development

regulation of adipose tissue development [inference]

positive regulation of adipose tissue development

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

positive regulation of membrane depolarization [inference]

positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of ventricular cardiac muscle cell action potential

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of T cell cytokine production

regulation of ossification [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of bone mineralization [inference]

negative regulation of bone mineralization

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of ventricular cardiac muscle cell action potential

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of ventricular cardiac muscle cell action potential

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac conduction [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of adipose tissue development

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of cardiac muscle cell action potential [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

positive regulation of cytosolic calcium ion concentration

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of membrane potential [inference]

regulation of membrane depolarization [inference]

positive regulation of membrane depolarization [inference]

positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential [inference]

membrane depolarization during cardiac muscle cell action potential [inference]

regulation of action potential [inference]

positive regulation of action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of cardiac muscle cell action potential [inference]

regulation of atrial cardiac muscle cell action potential [inference]

positive regulation of atrial cardiac muscle cell action potential

regulation of ventricular cardiac muscle cell action potential

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
endoplasmic reticulum	IDA	19945433
Golgi apparatus	IDA	19945433
plasma membrane	TAS
plasma membrane	IDA	19945433 29211723

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
calcium-activated cation channel activity	ISS
calcium-activated cation channel activity	IDA	27207958 29211723
calcium-activated cation channel activity	IBA
calcium channel activity	IEA
sodium channel activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

monoatomic ion-gated channel activity [inference]

calcium-activated cation channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transient receptor potential cation channel

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ligand-gated calcium channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Ion transport domain
TRPM, SLOG domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080766	erythrokeratodermia variabilis et progressiva 6	Alliance of Genome Resources
DOID:0111076	progressive familial heart block type IB	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54795	Xenbase:XB-GENE-960842
Mus musculus	68667	Xenbase:XB-GENE-960842	MOUSE54378
Rattus norvegicus	171143		RATNO15761
Pan troglodytes	456197		PANTR18902
Canis lupus familiaris	484385		CANLF00818
Macaca mulatta	719120		MACMU18700
Danio rerio	799647		DANRE04775
Danio rerio	100004946		DANRE31321
Callithrix jacchus	100408384		CALJA24756
Pongo abelii	100460849		PONAB14145

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements