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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

LMBR1 domain containing 1

Summary

Gene Symbol

LMBRD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

55788

KEGG Gene ID

PubChem

55788

Alliance of Genome Resources

HGNC:23038

Annotation

Keyword

Alternative splicing
Cell membrane
Cobalamin
Cytoplasmic vesicle
Endocytosis
Endoplasmic reticulum
Gastrulation
Glycoprotein
Host-virus interaction
Lysosome
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NUN5	HDAg-L-interacting protein NESI LMBR1 domain-containing protein 1 Nuclear export signal-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
gastrulation	ISS
gastrulation	IEA
insulin receptor internalization	ISS
insulin receptor internalization	IEA
protein localization to lysosome	IDA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
lysosome	IEA
lysosomal membrane	EXP
lysosomal membrane	TAS
lysosomal membrane	IDA
lysosomal membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
insulin receptor binding	IEA
protein binding	IPI
ABC-type vitamin B12 transporter activity	IDA
cobalamin binding
clathrin heavy chain binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type vitamin B12 transporter activity

vitamin transmembrane transporter activity

ABC-type vitamin B12 transporter activity

protein transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

tetrapyrrole binding [inference]

cobalamin binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type vitamin B12 transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosomal cobalamin transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cobalamin binding
protein localization to lysosome

Displaying 1 entry
InterPro
LMBR1-like membrane protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050717	methylmalonic aciduria and homocystinuria type cblF	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	68421	MGI:1915671
Rattus norvegicus	246046	RGD:708471
Danio rerio	323720	ZFIN:ZDB-GENE-041212-36
Xenopus laevis	398468	Xenbase:XB-GENE-1015713
Xenopus tropicalis	779630	Xenbase:XB-GENE-1015707

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026