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MIRAGE

LMBR1 domain containing 1

Summary

Gene Symbol

Lmbrd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68421

KEGG Gene ID

PubChem

68421

Alliance of Genome Resources

MGI:1915671

Annotation

Keyword

Alternative splicing
Cell membrane
Cobalamin
Cytoplasmic vesicle
Endocytosis
Endoplasmic reticulum
Gastrulation
Glycoprotein
Lysosome
Phosphoprotein
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K0B2	LMBR1 domain-containing protein 1 Protein N90b

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
gastrulation	IMP
insulin receptor internalization	IMP
negative regulation of D-glucose import across plasma membrane	IMP
negative regulation of insulin receptor signaling pathway	IMP
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
lysosome	IDA
lysosomal membrane	ISS
lysosomal membrane	ISO
lysosomal membrane	IBA
lysosomal membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
insulin receptor binding	IDA
protein binding	IPI
cobalamin binding
clathrin heavy chain binding	IDA
AP-2 adaptor complex binding	IMP

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosomal cobalamin transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cobalamin binding
protein localization to lysosome

Displaying 1 entry
InterPro
LMBR1-like membrane protein

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026