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Lysosomal cobalamin transport escort protein LMBD1

Summary

UniProt ID: Q8K0B2
Gene Symbol: Lmbrd1
Gene ID: 68421
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0006726
GlyGen: Q8K0B2
PubChem: Q8K0B2
Re-Glyco: Q8K0B2

Annotation

Keyword: Alternative splicing Cell membrane Cobalamin Cytoplasmic vesicle Endocytosis Endoplasmic reticulum Gastrulation Glycoprotein Lysosome Phosphoprotein Reference proteome Transmembrane helix Transport

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
gastrulation	IMP	PMID
insulin receptor internalization	IMP	PMID
negative regulation of D-glucose import across plasma membrane	IMP	PMID
negative regulation of insulin receptor signaling pathway	IMP	PMID
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
lysosome	IDA	PMID
lysosomal membrane	ISS	GO_REF
lysosomal membrane	ISO	GO_REF
lysosomal membrane	IBA	GO_REF
lysosomal membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying **all 5** entries
GO Term	Evidence Code	Reference
insulin receptor binding	IDA	PMID
cobalamin binding
clathrin heavy chain binding	IDA	PMID
AP-2 adaptor complex binding	IMP	PMID
protein transporter activity

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	GlyTouCan ID	Source
75	N-linked (GlcNAc...) asparagine		UniProt GlyGen
85	N-linked (GlcNAc...) asparagine		UniProt GlyGen
166	N-linked (GlcNAc...) asparagine		UniProt GlyGen
167	N-linked (GlcNAc...) asparagine		UniProt GlyGen
344	N-linked (GlcNAc...) asparagine		UniProt GlyGen
445	N-linked (GlcNAc...) asparagine		UniProt GlyGen
454	N-linked (GlcNAc...) asparagine	G92275SC	GlycoProtDB UniProt GlyGen