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Guidelines

MIRAGE

DEAD-box helicase 28

Summary

Gene Symbol

DDX28

Organism

Homo sapiens (human)

External Links

NCBI Gene

55794

PubChem

55794

Alliance of Genome Resources

HGNC:17330

Annotation

Keyword

3D-structure
Helicase
Mitochondrion nucleoid
Nucleus
Reference proteome
Ribosome biogenesis
rRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NUL7	Mitochondrial DEAD box protein 28

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial large ribosomal subunit assembly	IMP	25683715
mitochondrial large ribosomal subunit assembly	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
nucleolus	IDA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

supramolecular complex [inference]

ribonucleoprotein granule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
RNA helicase activity	IEA
ATP binding	IEA
ATP hydrolysis activity	IEA
rRNA binding	IDA	25683715

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

rRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

RNA helicase activity

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55794	Xenbase:XB-GENE-969500
Mus musculus	71986		MOUSE57730
Rattus norvegicus	364995		RATNO14607
Pan troglodytes	454183		PANTR12661
Canis lupus familiaris	489747		CANLF16027
Bos taurus	539411		BOVIN10666
Macaca mulatta	701929		MACMU26021
Danio rerio	768189		DANRE40359
Monodelphis domestica	100021849		MONDO05026
Pongo abelii	100457026		PONAB11171

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Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.3.0

Last updated: August 4, 2025