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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

protein tyrosine phosphatase receptor type B

Summary

Gene Symbol

PTPRB

Organism

Homo sapiens (human)

External Links

NCBI Gene

5787

KEGG Gene ID

PubChem

5787

Alliance of Genome Resources

HGNC:9665

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Glycoprotein
Phosphoprotein
Protein phosphatase
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q86VA4
F8VU56	Vascular endothelial protein tyrosine phosphatase
P23467	Vascular endothelial protein tyrosine phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	TAS
glial cell migration	IEA
dephosphorylation	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

dephosphorylation

protein dephosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell motility [inference]

cell migration [inference]

glial cell migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IC
membrane	IEA
specific granule membrane	TAS
signaling receptor complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
cadherin binding	IPI
cadherin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

signaling receptor inhibitor activity [inference]

transmembrane receptor protein tyrosine kinase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor-type tyrosine-protein phosphatase beta

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
angiogenesis
cadherin binding

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
PTPRJ, transmembrane domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060108	brain glioma	Alliance of Genome Resources
DOID:0001816	angiosarcoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:1115	sarcoma	Alliance of Genome Resources
DOID:4511	breast angiosarcoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	19263	MGI:97809
Caenorhabditis elegans	174437	WB:WBGene00009717
Drosophila melanogaster	32115	FB:FBgn0004370

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026