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butyrylcholinesterase

Summary

Gene Symbol

BCHE

Organism

Homo sapiens (human)

External Links

NCBI Gene

590

KEGG Gene ID

PubChem

590

Alliance of Genome Resources

HGNC:983

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Serine esterase
Sialic acid
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P06276	Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
acetylcholine catabolic process	IBA
xenobiotic metabolic process	TAS
response to nutrient	IEA
learning	IEA
negative regulation of cell population proliferation	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

acetylcholine metabolic process [inference]

acetylcholine catabolic process

catabolic process [inference]

acetylcholine catabolic process

alkaloid catabolic process [inference]

cocaine catabolic process

alkaloid metabolic process [inference]

alkaloid catabolic process [inference]

cocaine catabolic process

choline metabolic process

hormone metabolic process [inference]

peptide hormone processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nutrient levels [inference]

response to nutrient

response to vitamin [inference]

response to folic acid

response to chemical [inference]

response to nutrient

response to vitamin [inference]

response to folic acid

response to xenobiotic stimulus

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nitrogen compound [inference]

response to oxygen-containing compound [inference]

response to folic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS
extracellular region	TAS
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle envelope lumen [inference]

nuclear envelope lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

blood microparticle

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	NAS
catalytic activity	NAS
acetylcholinesterase activity	ISS
acetylcholinesterase activity	IBA
acetylcholinesterase activity	IEA

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

choline binding

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	12038	MGI:894278
Caenorhabditis elegans	175076	WB:WBGene00000037
Caenorhabditis elegans	171905	WB:WBGene00000036
Caenorhabditis elegans	181706	WB:WBGene00000035
Drosophila melanogaster	41625	FB:FBgn0000024

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements