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Cholinesterase

Summary

UniProt ID: P06276
Gene Symbol: BCHE CHE1
Gene ID: 590
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011403

GlyConnect

Cholinesterase

GlyGen

P06276

PubChem

P06276

The Human Metabolome Database

HMDBP00525

Re-Glyco

P06276

Annotation

Keyword: 3D-structure Direct protein sequencing Disease variant Disulfide bond Phosphoprotein Proteomics identification Reference proteome Secreted Serine esterase Sialic acid Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
acetylcholine catabolic process	IBA	GO_REF
xenobiotic metabolic process	TAS	Reactome
learning	IEA	GO_REF
negative regulation of cell population proliferation	IEA	GO_REF
neuroblast differentiation	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

acetylcholine metabolic process [inference]

acetylcholine catabolic process

catabolic process [inference]

acetylcholine catabolic process

alkaloid catabolic process [inference]

cocaine catabolic process

alkaloid metabolic process [inference]

alkaloid catabolic process [inference]

cocaine catabolic process

choline metabolic process

hormone metabolic process [inference]

peptide hormone processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nitrogen compound [inference]

response to oxygen-containing compound [inference]

response to folic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome
extracellular region	IEA	GO_REF GO_REF
obsolete extracellular space
nuclear envelope lumen	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle envelope lumen [inference]

nuclear envelope lumen

blood microparticle

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GO Term	Evidence Code	Reference
amyloid-beta binding	NAS	PMID
catalytic activity	NAS	PMID
acetylcholinesterase activity	ISS	GO_REF
acetylcholinesterase activity	IBA	GO_REF
acetylcholinesterase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

choline binding

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 12 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
45	N-linked (GlcNAc...) (complex) asparagine	16335952 18203274 37074911	G43223CG G08918WF G00912UN G27058EU G80920RR	UniProt GlyGen
85	N-linked (GlcNAc...) (complex) asparagine	12869558 15667209 16335952 17355286 17768338 18203274 18975951 19368529 23679855 24190977 29391424 29741879 34089345 37074911	G70232NH G06247RL G27947YN G22310AV G45395BF G40574BA G08918WF G00912UN G48414YA G83460ZZ G70619PT G59626AS G80920RR G62765YT	GlycoProtDB UniProt GlyGen GlyConnect
134	N-linked (GlcNAc...) (complex) asparagine	12869558 15667209 17355286 17768338 18203274 18975951 19159218 19368529 23679855	G92551JA	UniProt GlyGen
256				GlyGen
269	N-linked (GlcNAc...) (complex) asparagine	12869558 15667209 17355286 18203274 19368529 23679855		UniProt GlyGen
284	N-linked (GlcNAc...) (complex) asparagine	18203274 18975951 19139490 19159218 19368529 23679855 24190977 29391424 34089345 37074911	G37881RL G86795LJ G22310AV G40574BA G00912UN G83646BJ G59626AS G01650EU G80920RR G37399XV G62765YT G28541PG G95865ZB G31852PQ G11314AS G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
369	N-linked (GlcNAc...) (complex) asparagine	12869558 15667209 16335952 17355286 17768338 18203274 18975951 19368529 23679855 24190977 29391424 34089345 37074911	G43089EG G22310AV G00912UN G70441OD G59626AS G62765YT G31852PQ G41247ZX	UniProt GlyGen GlyConnect
483	N-linked (GlcNAc...) (complex) asparagine	16335952 18203274 24190977	G80920RR	GlycoProtDB UniProt GlyGen
507				GlyGen
509	N-linked (GlcNAc...) asparagine	14760718 16335952 29391424 3542989	G12270AG G62461SM G55412XP G13694XX G15169WU G37881RL G11629QQ G81263BG G22310AV G48414YA G84452RH	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Aspirin ADME	Homo sapiens
Neurotransmitter clearance	Homo sapiens
Synthesis of PC	Homo sapiens
Synthesis, secretion, and deacylation of Ghrelin	Homo sapiens

Disease

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements