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Rh associated glycoprotein

Summary

Gene Symbol

RHAG

Organism

Homo sapiens (human)

External Links

NCBI Gene

6005

PubChem

6005

Alliance of Genome Resources

HGNC:10006

Annotation

Keyword

3D-structure
Alternative splicing
Ammonia transport
Direct protein sequencing
Disease variant
Glycoprotein
Hereditary hemolytic anemia
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96E98	Erythrocyte membrane glycoprotein Rh50 Rhesus blood group family type A glycoprotein
Q02094	Erythrocyte membrane glycoprotein Rh50 Erythrocyte plasma membrane 50 kDa glycoprotein Rhesus blood group family type A glycoprotein Rhesus blood group-associated ammonia channel Rhesus blood group-associated glycoprotein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
intracellular monoatomic ion homeostasis	IDA	15856280
carbon dioxide transport	IDA	16574458 17712059 19273840 24077989
bicarbonate transport	TAS
carbon dioxide transmembrane transport	IDA	19273840
erythrocyte development	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

ammonium transmembrane transport

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

gas transport [inference]

carbon dioxide transport

carbon dioxide transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

ammonium transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

methylammonium transport [inference]

methylammonium transmembrane transport

organic anion transport [inference]

bicarbonate transport

amine transport [inference]

methylammonium transport [inference]

methylammonium transmembrane transport

one-carbon compound transport [inference]

carbon dioxide transport

carbon dioxide transmembrane transport

bicarbonate transport

methylammonium transport [inference]

methylammonium transmembrane transport

nitrogen compound transport [inference]

amine transport [inference]

methylammonium transport [inference]

methylammonium transmembrane transport

ammonium transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	15929723 27247322
plasma membrane	IBA
membrane	IDA	22012326
ankyrin-1 complex	IDA	35835865

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

ankyrin-1 complex

cellular anatomical entity [inference]

membrane

plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	32296183
ammonium transmembrane transporter activity	TAS
ammonium transmembrane transporter activity	IDA	15856280 15929723 16866382 17712059 19273840 24077989 26354748
ammonium transmembrane transporter activity	IGI	11062476
ammonium transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity

organic cation transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

ammonium transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

ammonium transmembrane transporter activity

narrow pore channel activity [inference]

leak channel activity

carbon dioxide transmembrane transporter activity

salt transmembrane transporter activity [inference]

methylammonium transmembrane transporter activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

ankyrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ammonium transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Ammonium transporter AmtB-like domain
Ammonium transporter, conserved site
Ammonium transporter
Ammonium/urea transporter

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050641	Rh deficiency syndrome	Alliance of Genome Resources
DOID:0111562	overhydrated hereditary stomatocytosis	Alliance of Genome Resources
DOID:583	hemolytic anemia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6005	Xenbase:XB-GENE-983543
Mus musculus	19743	Xenbase:XB-GENE-983543	MOUSE21754
Caenorhabditis elegans	19746	WB:WBGene00004359
Caenorhabditis elegans	51458	WB:WBGene00004359
Caenorhabditis elegans	56315	WB:WBGene00004358
Caenorhabditis elegans	57127	WB:WBGene00004359
Caenorhabditis elegans	58176	WB:WBGene00004359
Rattus norvegicus	65207	Xenbase:XB-GENE-983543	RATNO42637
Caenorhabditis elegans	293048	WB:WBGene00004358
Caenorhabditis elegans	310625	WB:WBGene00004359

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OrthoDB (Group)

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Acknowledgements