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glutamate metabotropic receptor 8

Summary

Gene Symbol

Grm8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

60590

PubChem

60590

Alliance of Genome Resources

RGD:619858

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Reference proteome
Sensory transduction
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P70579
A6IEA3
F1LRA6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISS
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	TAS	16084932
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	16045496
plasma membrane	IBA
plasma membrane	IEA
presynaptic membrane	IDA	15275822
neuronal cell body	IDA	12443992

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
group III metabotropic glutamate receptor activity	ISO
group III metabotropic glutamate receptor activity	IDA	9875342
group III metabotropic glutamate receptor activity	IBA
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	ISO

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 6** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
neuronal cell body	PMID:12443992

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 99 in total

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Species	Gene ID	Orthologous MAtrix
Danio rerio	569768	DANRE27644
Macaca mulatta	697465	MACMU33211
Taeniopygia guttata	751963	TAEGU08720
Danio rerio	792371	DANRE32804
Equus caballus	100071655	HORSE32079
Ornithorhynchus anatinus	100077390	ORNAN00838
Papio anubis	100137389	PAPAN30636
Oryctolagus cuniculus	100344818	RABIT11462
Callithrix jacchus	100390040	CALJA42839
Pongo abelii	100436264	PONAB32643