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actinin alpha 4

Summary

Gene Symbol

Actn4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

60595

KEGG Gene ID

PubChem

60595

Alliance of Genome Resources

MGI:1890773

Annotation

Keyword

Acetylation
Actin-binding
Calcium
Cell junction
Coiled coil
Cytoskeleton
Direct protein sequencing
Metal-binding
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P57780	Non-muscle alpha-actinin 4
Q3ULT2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
gene expression	IMP
protein transport
actin cytoskeleton organization	IBA
vesicle transport along actin filament	ISO
positive regulation of cell migration	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

hormone-mediated signaling pathway [inference]

retinoic acid receptor signaling pathway

intracellular signal transduction [inference]

intracellular receptor signaling pathway [inference]

nuclear receptor-mediated signaling pathway [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

actin filament-based process [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

actin filament-based movement [inference]

vesicle transport along actin filament

cellular developmental process [inference]

cell development [inference]

muscle cell development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

podocyte cell migration

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

actin filament-based transport [inference]

vesicle transport along actin filament

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

actin filament bundle assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly

developmental process [inference]

anatomical structure development [inference]

glomerulus development

cell development [inference]

muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

protein localization to cell junction [inference]

protein localization to cell-cell junction [inference]

protein localization to bicellular tight junction

establishment of localization [inference]

transport [inference]

protein transport

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

actin filament-based transport [inference]

vesicle transport along actin filament

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

actin filament-based transport [inference]

vesicle transport along actin filament

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

actin filament-based transport [inference]

vesicle transport along actin filament

vesicle cytoskeletal trafficking [inference]

vesicle transport along actin filament

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

hormone-mediated signaling pathway [inference]

retinoic acid receptor signaling pathway

intracellular signal transduction [inference]

intracellular receptor signaling pathway [inference]

nuclear receptor-mediated signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of pinocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
stress fiber	ISO
stress fiber	IDA
stress fiber	IEA
nucleus	ISS
nucleus	ISO

GO Hierarchy

cellular component

protein-containing complex

ribonucleoprotein complex

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

Z disc

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction

cell-cell junction

cell-substrate junction [inference]

focal adhesion

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

perinuclear region of cytoplasm

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO
nucleoside binding	ISO
transcription coactivator activity	ISS
transcription coactivator activity	ISO
structural constituent of cytoskeleton	IMP