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MIRAGE
complement factor B
Summary
- Gene Symbol
-
- CFB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cleavage on pair of basic residues
- Complement alternate pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycation
- Glycoprotein
- Hemolytic uremic syndrome
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P00751 |
|
| A0A1U9X7H8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| complement activation | ||
| complement activation, alternative pathway | ||
| complement activation, alternative pathway | ||
| response to bacterium |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| plasma membrane | ||
| extracellular exosome | ||
| blood microparticle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| complement binding | ||
| serine-type endopeptidase activity | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Complement factor B
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Sushi/SCR/CCP domain |
| Sushi/SCR/CCP superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:0110026 | age related macular degeneration 14 | |
| DOID:10923 | sickle cell anemia | |
| DOID:10976 | membranous glomerulonephritis | |
| DOID:1407 | anterior uveitis | |
| DOID:2920 | membranoproliferative glomerulonephritis | |
| DOID:2986 | IgA glomerulonephritis | |
| DOID:4448 | macular degeneration | |
| DOID:8893 | psoriasis | |
| DOID:8947 | diabetic retinopathy |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100715616 | CAVPO08832 | ||
| 100758781 | CRIGR18048 | ||
| 101036079 | SAIBB39511 | ||
| 101093018 | FELCA11989 | ||
| 101317049 | TURTR05366 | ||
| 101569118 | OCTDE02152 | ||
| 101603571 | JACJA24069 | ||
| 101725137 | HETGA14735 | ||
| 102005413 | CHILA10080 | ||
| 102175816 | CAPHI15474 |
