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Guidelines

MIRAGE

N-deacetylase and N-sulfotransferase 4

Summary

Gene Symbol

NDST4

Organism

Homo sapiens (human)

External Links

NCBI Gene

64579

GGDB ID

gg023

HGNC

20779

mRNA

NM_022569

map

4q25-q26

Protein

NP_072091

OMIM

615039

KEGG Gene ID

hsa:64579

PubChem

64579

Alliance of Genome Resources

HGNC:20779

JoGo

NDST4

TogoVar

NDST4

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Golgi apparatus
Hydrolase
Multifunctional enzyme
Proteomics identification
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K0V5
Q9H3R1	Glucosaminyl N-deacetylase/N-sulfotransferase 4 N-heparan sulfate sulfotransferase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
heparan sulfate proteoglycan biosynthetic process	IBA
heparan sulfate proteoglycan biosynthetic process	IEA
heparin proteoglycan biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process [inference]

heparin proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	IEA
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
sulfotransferase activity	IEA
heparan sulfate N-sulfotransferase activity	IBA
heparan sulfate N-sulfotransferase activity	IEA
hydrolase activity	IEA
deacetylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

proteoglycan sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

heparan sulfate N-sulfotransferase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylglucosamine deacetylase activity

deacylase activity [inference]

deacetylase activity

N-acetylglucosamine deacetylase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg023

Gene Symbol

NDST4

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_072087	NM_022565
Rattus norvegicus	XP_342337	XM_342336

KEGG BRITE Database

Orthology

K02579

Name

heparan sulfate N-deacetylase/N-sulfotransferase NDST4 [EC:3.5.1.- 2.8.2.8]

References

11087757

Rhea

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.8

PMID

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	64580	MGI:1932545
Rattus norvegicus	362035	RGD:1306531
Caenorhabditis elegans	177675	WB:WBGene00002028
Drosophila melanogaster	38736	FB:FBgn0020251
Danio rerio	100317129	ZFIN:ZDB-GENE-090312-199
Xenopus laevis	108706714	Xenbase:XB-GENE-6488840
Xenopus laevis	108710452	Xenbase:XB-GENE-17337061
Xenopus tropicalis	100380006	Xenbase:XB-GENE-951845

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026