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Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Summary
- UniProt ID
- Q9H3R1
- Gene Symbol
-
- NDST4
- HSST4
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9H3R1
- The Human Metabolome Database
- HMDBP11856
- The O-GlcNAc Database
- Q9H3R1
Annotation
- Keyword
-
- Alternative splicing
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Hydrolase
- Multifunctional enzyme
- Proteomics identification
- Reference proteome
- Signal-anchor
- Transferase
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| heparin biosynthetic process |
| heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| GO Term |
|---|
| N-acetylglucosamine deacetylase activity |
| [heparan sulfate]-glucosamine N-sulfotransferase activity |
| deacetylase activity |
Sequence
MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPYRSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYHMVIAPGKGDIPPLTDNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVSIIGFHKANENSLPSTQLKGFPLNLFNNLALKDCFVNPQSPLLHITKAPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQTEKSLSSLSSKTLFATVIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEEDEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINMGYAVAPHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIRGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLVNFVQSWTNLKLQTLPPVQLAHQYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIDWYMDFFPTPSNTTSDFLFEKSANYFHSEEAPRRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNFYEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYFATSQLLIIDGQQLRSDPATVMDEVQKFLGVTPRYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDPESRTFLSNYYRDHNVELSKLLHRLGQPLPSWLRQELQKVR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 226 | N-linked (GlcNAc...) asparagine |
|
||
| 341 | N-linked (GlcNAc...) asparagine |
|
||
| 391 | N-linked (GlcNAc...) asparagine |
|
||
| 657 | N-linked (GlcNAc...) asparagine |
|
||
| 793 | N-linked (GlcNAc...) asparagine |
|
||
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG biosynthesis | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080199 | colorectal carcinoma | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:13739 | nutmeg liver | |
| DOID:162 | cancer | |
| DOID:1936 | atherosclerosis | |
| DOID:2348 | arteriosclerotic cardiovascular disease | |
| DOID:3393 | coronary artery disease | |
| DOID:4766 | embryoma | |
| DOID:5672 | large intestine cancer |
