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Submissions

solute carrier family 2 member 1

Summary

Gene Symbol

SLC2A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6513

KEGG Gene ID

PubChem

6513

Alliance of Genome Resources

HGNC:11005

Annotation

Keyword

3D-structure
Acetylation
Cataract
Cell membrane
Direct protein sequencing
Disease variant
Dystonia
Epilepsy
Glycoprotein
Hereditary hemolytic anemia
Intellectual disability
Phosphoprotein
Proteomics identification
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P11166	Glucose transporter type 1, erythrocyte/brain HepG2 glucose transporter
Q59GX2	Glucose transporter type 1, erythrocyte/brain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
central nervous system development	IMP
female pregnancy	IEA
fucose transmembrane transport	IEA
long-chain fatty acid import across plasma membrane	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

metabolic compound salvage [inference]

GDP-L-fucose salvage

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

system development [inference]

central nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to chemical [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

response to Thyroglobulin triiodothyronine

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

dehydroascorbic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

xenobiotic transport

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

Displaying entries **1 - 5** of 44 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
female germ cell nucleus
photoreceptor inner segment	ISS
photoreceptor inner segment	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

glucose transporter complex

cellular anatomical structure [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell-cell contact zone [inference]

intercalated disc

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid transmembrane transporter activity	IMP
protein binding	IPI
fucose transmembrane transporter activity	IEA
kinase binding	IEA
transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

xenobiotic transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2 (facilitated glucose

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hexose transmembrane transporter activity

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources
DOID:0070560	glucose transporter type 1 deficiency syndrome	Alliance of Genome Resources
DOID:0090044	dystonia 9	Alliance of Genome Resources
DOID:0060326	myelomeningocele	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:0070561	glucose transporter type 1 deficiency syndrome 1	Alliance of Genome Resources
DOID:0090045	glucose transporter type 1 deficiency syndrome 2	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:0111313	obsolete idiopathic generalized epilepsy 12	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20525	MGI:95755
Rattus norvegicus	24778	RGD:3704
Drosophila melanogaster	38109	FB:FBgn0264574
Saccharomyces cerevisiae S288C	852543	SGD:S000000445

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements