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Solute carrier family 2, facilitated glucose transporter member 1

Summary

UniProt ID: P11166
Gene Symbol: GLUT1 SLC2A1
Gene ID: 6513
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011486

GlyConnect

Solute carrier family 2, facilitated glucose transporter, member 1

GlyGen

P11166

PubChem

P11166

The Human Metabolome Database

HMDBP02114

The O-GlcNAc Database

P11166

RaftProt

P11166

O-GlcNAcAtlas

P11166

Re-Glyco

P11166

Annotation

Keyword: 3D-structure Acetylation Cataract Cell membrane Direct protein sequencing Disease variant Dystonia Epilepsy Glycoprotein Hereditary hemolytic anemia Intellectual disability Phosphoprotein Proteomics identification Reference proteome Sugar transport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	Reference
response to hypoxia	IEA	GO_REF
central nervous system development	IMP	PMID PMID
female pregnancy	IEA	GO_REF
long-chain fatty acid import across plasma membrane	IMP	PMID
L-ascorbic acid metabolic process	TAS	Reactome

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

metabolic compound salvage [inference]

GDP-L-fucose salvage

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

GDP-L-fucose metabolic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-L-fucose biosynthetic process [inference]

GDP-L-fucose salvage

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

system development [inference]

central nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to chemical [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

response to Thyroglobulin triiodothyronine

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

dehydroascorbic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

D-glucose transmembrane transport

D-glucose import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

D-glucose import across plasma membrane

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	Reference
Golgi membrane	TAS	Reactome
Golgi membrane	IEA	GO_REF
female germ cell nucleus
photoreceptor inner segment	ISS	GO_REF
photoreceptor inner segment	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

glucose transporter complex

cellular anatomical structure [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
long-chain fatty acid transmembrane transporter activity	IMP	PMID
fucose transmembrane transporter activity	IEA	GO_REF
kinase binding	IEA	GO_REF
dehydroascorbic acid transmembrane transporter activity	EXP	PMID PMID
dehydroascorbic acid transmembrane transporter activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

xenobiotic transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding

identical protein binding

Gene Ontology information from UniProt.

Site Annotations

Displaying 1 entry
Position	Description
411	Not glycosylated

Annotation information from UniProt.

Sequence

MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
45	N-linked (GlcNAc...) asparagine	19349973 24190977 37074911 3839598	G11115RO G44753VC G68490OW G98611JV G80920RR G11314AS	GlycoProtDB UniProt GlyGen
465		18984734 34019948 34725712 35083852 40367522 40596516 41018975	G49108TO	GlyGen The O-GlcNAc Database GlyConnect
unknown		2271582	G60230HH G70101JE	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Cellular hexose transport	Homo sapiens
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	Homo sapiens
Lactose synthesis	Homo sapiens
Regulation of insulin secretion	Homo sapiens
Vitamin C (ascorbate) metabolism	Homo sapiens

Human Protein Atlas

ENSG00000117394

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0070560	glucose transporter type 1 deficiency syndrome	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:0090044	dystonia 9	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:0060326	myelomeningocele	Alliance of Genome Resources
DOID:0070561	glucose transporter type 1 deficiency syndrome 1	Alliance of Genome Resources
DOID:0090045	glucose transporter type 1 deficiency syndrome 2	Alliance of Genome Resources
DOID:0111313	obsolete idiopathic generalized epilepsy 12	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements