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Vitamin C (ascorbate) metabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-196836

PubChem

R-HSA-196836

Description

Vitamin C (ascorbate) is an antioxidant and a cofactor in reactions catalyzed by Cu+-dependent monooxygenases and Fe++-dependent dioxygenases. Many mammals can synthesize ascorbate de novo; humans and other primates cannot due to an evolutionarily recent mutation in the gene catalyzing the last step of the biosynthetic pathway. Reactions annotated here mediate the uptake of ascorbate and its fully oxidized form, dehydroascorbate (DHA) by cells, and the reduction of DHA and monodehydroascorbate to regenerate ascorbate (Linster and Van Schaftingen 2007).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00387	NADH-cytochrome b5 reductase 3	CYB5R3 DIA1	view
P11166	Solute carrier family 2, facilitated glucose transporter member 1	GLUT1 SLC2A1	view
P11169	Solute carrier family 2, facilitated glucose transporter member 3	GLUT3 SLC2A3	view
P78417	Glutathione S-transferase omega-1	GSTO1 GSTTLP28	view
Q9UGH3	Solute carrier family 23 member 2	KIAA0238 NBTL1 SLC23A1 SLC23A2 SVCT2 YSPL2	view
Q9UHI7	Solute carrier family 23 member 1	SLC23A1 SVCT1 YSPL3	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002579	P11169	Solute carrier family 2, facilitated glucose transporter member 3	view

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