GlyCosmos Portal

Submissions

solute carrier family 22 member 5

Summary

Gene Symbol

SLC22A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

6584

KEGG Gene ID

PubChem

6584

Alliance of Genome Resources

HGNC:10969

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Disease variant
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O76082	High-affinity sodium-dependent carnitine cotransporter Solute carrier family 22 member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
sodium ion transport
response to symbiotic bacterium	IMP
organic cation transport	IEA
quaternary ammonium group transport	IDA
quaternary ammonium group transport	IMP

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

carnitine transmembrane transport

(R)-carnitine transmembrane transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

vascular transport [inference]

transport across blood-brain barrier

organic cation transport

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

sodium-dependent organic cation transport

xenobiotic transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

carnitine transmembrane transport

(R)-carnitine transmembrane transport

nitrogen compound transport [inference]

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

amine transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of intestinal epithelial structure maintenance [inference]

positive regulation of intestinal epithelial structure maintenance

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

Displaying entries **1 - 5** of 20 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
cytoplasm	ISS
endoplasmic reticulum	EXP
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
cytosol	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 21 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IEA
obsolete organic cation transmembrane transporter activity
amino-acid betaine transmembrane transporter activity	IDA
amino-acid betaine transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

xenobiotic transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:14365	systemic primary carnitine deficiency disease	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20520	MGI:1329012
Mus musculus	56517	MGI:1929481
Rattus norvegicus	29726	RGD:3702
Caenorhabditis elegans	172841	WB:WBGene00003842
Drosophila melanogaster	42890	FB:FBgn0086365
Drosophila melanogaster	42891	FB:FBgn0019952
Saccharomyces cerevisiae S288C	850462	SGD:S000000695