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Guidelines

MIRAGE

clathrin heavy chain

Summary

Gene Symbol

Cltc

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67300

KEGG Gene ID

PubChem

67300

Alliance of Genome Resources

MGI:2388633

Annotation

Keyword

3D-structure
Acetylation
Autophagy
Coated pit
Cytoplasmic vesicle
Cytoskeleton
Direct protein sequencing
Mitosis
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q68FD5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	ISO
mitotic cell cycle	IBA
mitotic cell cycle	IEA
intracellular protein transport	IEA
receptor-mediated endocytosis	ISO

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cell cycle [inference]

mitotic cell cycle

metabolic process [inference]

catabolic process [inference]

autophagy

intercellular transport [inference]

retrograde transport, endosome to Golgi

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

transcytosis [inference]

amyloid-beta clearance by transcytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cell division

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

Golgi organization

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

protein-containing complex assembly [inference]

clathrin coat assembly

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

transferrin transport

intercellular transport [inference]

retrograde transport, endosome to Golgi

protein transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

transcytosis [inference]

amyloid-beta clearance by transcytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of protein localization [inference]

protein transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA
lysosome	ISO
lysosome	IEA
endosome	ISO
endosome	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

vesicle coat [inference]

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

clathrin complex

plasma membrane protein complex [inference]

clathrin coat of coated pit

nuclear protein-containing complex [inference]

Myb complex

cellular anatomical structure [inference]

plasma membrane [inference]

sarcolemma

clathrin-coated pit

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic endocytic zone membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell junction [inference]

synapse [inference]

ribbon synapse [inference]

photoreceptor ribbon synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

intracellular membraneless organelle [inference]

mitotic spindle

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule [inference]

mitotic spindle microtubule

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
double-stranded RNA binding	ISO
double-stranded RNA binding	IEA
structural molecule activity	IEA
protein binding	IPI
protein kinase binding	IPI

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

cytoskeletal protein binding [inference]

ankyrin binding

enzyme binding [inference]

protease binding [inference]

ubiquitin-specific protease binding

kinase binding [inference]

protein kinase binding

protein serine/threonine kinase binding

protein domain specific binding [inference]

disordered domain specific binding

clathrin binding [inference]

clathrin light chain binding

heat shock protein binding

peptide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CLATHRIN HEAVY CHAIN

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
clathrin light chain binding
receptor-mediated endocytosis
structural molecule activity

Displaying **all 7** entries
InterPro
Armadillo-type fold
Clathrin heavy chain, N-terminal
Clathrin, heavy chain, linker, core motif
Clathrin, heavy chain, propeller repeat
Clathrin, heavy chain/VPS, 7-fold repeat
Clathrin, heavy chain
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1213	HGNC:2092

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Last updated: April 6, 2026