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Clathrin heavy chain 1

Summary

UniProt ID: Q68FD5
Gene Symbol: Cltc
Gene ID: 67300
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q68FD5
PubChem: Q68FD5
RaftProt: Q68FD5
Re-Glyco: Q68FD5

Annotation

Keyword: 3D-structure Acetylation Autophagy Coated pit Cytoplasmic vesicle Cytoskeleton Direct protein sequencing Mitosis Phosphoprotein Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	Reference
mitotic cell cycle	ISO	GO_REF GO_REF
mitotic cell cycle	IBA	GO_REF
mitotic cell cycle	IEA	GO_REF
intracellular protein transport	IEA	GO_REF
receptor-mediated endocytosis	ISO	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cell cycle [inference]

mitotic cell cycle

metabolic process [inference]

catabolic process [inference]

autophagy

intercellular transport [inference]

retrograde transport, endosome to Golgi

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

transcytosis [inference]

amyloid-beta clearance by transcytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cell division

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

Golgi organization

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

protein-containing complex assembly [inference]

clathrin coat assembly

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

transferrin transport

intercellular transport [inference]

retrograde transport, endosome to Golgi

protein transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

transcytosis [inference]

amyloid-beta clearance by transcytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of protein localization [inference]

protein transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

Displaying entries **1 - 5** of 43 in total

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GO Term	Evidence Code	Reference
mitochondrion	HDA	PMID
lysosome	ISO	GO_REF
lysosome	IEA	GO_REF
endosome	ISO	GO_REF
endosome	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

membrane coat

clathrin coat

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

vesicle coat [inference]

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

clathrin complex

plasma membrane protein complex [inference]

clathrin coat of coated pit

nuclear protein-containing complex [inference]

Myb complex

cellular anatomical structure [inference]

cytosol

membrane

plasma membrane [inference]

sarcolemma

clathrin-coated pit

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic endocytic zone membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell junction [inference]

synapse [inference]

ribbon synapse [inference]

photoreceptor ribbon synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

pigment granule [inference]

melanosome

intracellular membraneless organelle [inference]

spindle

mitotic spindle

postsynaptic endocytic zone

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule [inference]

mitotic spindle microtubule

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GO Term	Evidence Code	Reference
double-stranded RNA binding	ISO	PMID
double-stranded RNA binding	IEA	GO_REF
structural molecule activity	IEA	GO_REF
protein kinase binding	IPI	PMID
ankyrin binding	ISO	GO_REF

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

protein binding [inference]

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

cytoskeletal protein binding [inference]

ankyrin binding

enzyme binding [inference]

protease binding [inference]

ubiquitin-specific protease binding

kinase binding [inference]

protein kinase binding

protein serine/threonine kinase binding

protein domain specific binding [inference]

disordered domain specific binding

clathrin binding [inference]

clathrin light chain binding

heat shock protein binding

peptide binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANASGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	GlyTouCan ID	Source
376	G37399XV	GlyGen
1220	G83014KM	GlyGen
1248	G39446WN	GlyGen
1460	G02815KT	GlyGen
1492	G50282JC	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 15 in total

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Pathway Name	Organism
Cargo recognition for clathrin-mediated endocytosis	Mus musculus
Clathrin-mediated endocytosis	Mus musculus
Formation of annular gap junctions	Mus musculus
Gap junction degradation	Mus musculus
Golgi Associated Vesicle Biogenesis	Mus musculus
LDL clearance	Mus musculus
Lysosome Vesicle Biogenesis	Mus musculus
MHC class II antigen presentation	Mus musculus
RHOU GTPase cycle	Mus musculus
RHOV GTPase cycle	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements